Modern Genetics
- Lafyva
- Jun 13, 2024
- 1 min read
Updated: Aug 26
Phylogenomic data acquisition: principles and practice
Synthetic receptors with both engineered sensing and engineered
actuation. Synthetic receptor systems that signal with both engineered
sensing and actuation can be orthogonal to, or completely independent
of, endogenous sensing and actuation. This strategy enables
construction of signaling pathways with both user-defined input and
output that do not rely on pre-existing natural receptors (Fig. 2).
Synthetic receptor development has evolved substantially from
modest modifications of natural proteins to design-driven construction,
refinement and integration of modular technologies that
increasingly enable true engineering of customized cellular functions.
Notably, key choices in the iterative refinement of CARs were
uniquely informed by evaluations in their final application context
(in this case, in clinical trials4). Evaluating other synthetic receptor
systems in application-specific contexts may prove similarly
useful for guiding both the development and use of these technologies.
These advances reflect a qualitative shift in the broader field
of mammalian synthetic biology, wherein progress is increasingly
guided by rational exploration and knowledge building, as opposed
to trial and error, toward new applications of greatest clinical,
scientific and societal benefit.
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